Spectrum: Local Antimicrobial Stewardship, for Saskatchewan Health Authority - Saskatoon Area

Meropenem

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

Standard Dose
500mg IV q6h or 1g IV q8h

Meningitis
2g IV q8h

Must be approved by Infectious Diseases or Critical Care

Restricted Use

General Information

Common Usage

Common Usage

Therapy of serious, often nosocomial infections involving resistant Gram negative organisms

Adverse Effects

Adverse Effects

  •  Immediate and delayed-type allergy

  •  GI disturbance

  •  Cytopenias, positive Coombs

  •  Liver enzyme abnormalities

Major Interactions

Major Interactions

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold

Pharmacology

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic