Spectrum: Local Antimicrobial Stewardship, for Saskatchewan Health Authority - Saskatoon Area

Ceftazidime

C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

Usual dosing
1-2g IV q8h

General Information

Common Usage

Common Usage

Ceftazidime is third generation cephalosporin with broad Gram negative coverage including coverage of Pseudomonas spp. and is generally used for nosocomial infections.

Ceftazidime lacks Gram positive activity compared to other cephalosporins.

Adverse Effects

Adverse Effects

  • Allergy/rash

  • Gastrointestinal intolerance

  • Clostridium difficile associated diarrhea

Major Interactions

Major Interactions

No significant interactions

Pharmacology

Pharmacology

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic