Spectrum: Local Antimicrobial Stewardship, for Saskatchewan Health Authority - Saskatoon Area

Vancomycin PO

C. diff Risk

NA

Oral Bioavailability

None

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

No dosing adjustments required

Hepatic

No dosing adjustments required

Adult

125mg PO QID for 14 days.

Intra-colonic dose
250mg in 100mL of NS by rectal enema q6h

General Information

Common Usage

Common Usage

Only indication is in the therapy of C. difficile infection, particularly recurrent or severe disease

Drug Monitoring

Drug Monitoring

Possibility of accumulation in severe renal dysfunction.

Additional Information

Additional Information

No oral absorption.

May increase vancomycin resistant Enterococci colonization in the gut.

Pharmacology

Pharmacology

Antimicrobial class: Glycopeptide

Pregnancy category: B

Average serum half life: 0 hours

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: None