Spectrum: Local Antimicrobial Stewardship, for Saskatchewan Health Authority - Saskatoon Area

Ceftriaxone

C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

No dosage adjustments required

Adult

Usual dosage
1-2g IV q24h

Community-acquired pneumonia
1-2g IV q24h

Community-acquired intra-abdominal infection
1-2g IV q24h

Bacterial Meningitis OR Intra-cranial abscess
2g IV q12h

Infective Endocarditis
2g IV q12-24h

Osteomyelitis
2g IV q24h

General Information

Common Usage

Common Usage

Ceftriaxone is commonly used as empiric treatment for bacterial meningitis, community-acquired pneumonia and community-acquired intra-abdominal infections.

Adverse Effects

Adverse Effects

  • Allergy/rash

  • Phlebitis

  • Cytopenias

  • Hepatic & renal laboratory abnormalities

  • Pseudocholelithiasis

  • Clostridium difficile associated diarrhea

Major Interactions

Major Interactions

Increased risk of QT prolongation in patients given both ceftriaxone and lansoprazole.

Pharmacology

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic