Trough Level Based on Indication

Low Trough Level (10 – 15 mg/L)

  • Skin and soft tissue infection not due to MRSA

  • Urinary tract infection (catheter associated; rule out bacteremia)

High Trough Level (15 – 20 mg/L)

  • Catheter-associated bacteremia

  • Central nervous system infection

  • Deep-seated or sequestered infection (ex. abscess)

  • Endocarditis

  • Osteomyelitis

  • MRSA bacteremia, pneumonia or skin and soft tissue infection

  • MSSA bacteremia (penicillin allergic patient)