Spectrum: Local Antimicrobial Stewardship, for Lake of the Woods District Hospital

Rifampicin (Rifampin, Rifadin)

C. diff Risk

NA

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Renal

No dosage adjustment necessary. Administer after hemodialysis on dialysis days.

General Information

Common Usage

Common Usage

  • Mycobacterial infections

  • Brucellosis

  • Osteomyelitis

  • Prosthetic joint infections due to Staphylococcus aureus

Always use in combination with other agents

Drug Monitoring

Drug Monitoring

Lab

  • Baseline and periodic LFTs

Clinical

  • Multiple drug interactions

Adverse Effects

Adverse Effects

  • Nausea/vomiting, diarrhea

  • Abnormal liver enzymes

  • Rash (Steven-Johnson syndrome)

  • Myopathy

Major Interactions

Major Interactions

Inducer of many CYP enzymes including 3A4, and 2C9. Review patients medications carefully.

Additional Information

Additional Information

  • Should never be used as monotherapy

  • May discolor bodily secretions (yellow-reddish). Caution in contact lens wearers.

Pharmacology

Pharmacology

Antimicrobial class: Antimycobacterial

Pregnancy category: C

Average serum half life: 3-4 hr

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Route of Elimination: Feces