Spectrum: Local Antimicrobial Stewardship, for Lake of the Woods District Hospital

Clindamycin (Dalacin)

C. diff Risk

High

Oral Bioavailability

Excellent

Approximate Cost

PO ~$1.00/day
IV ~$8.00/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Renal

No renal adjustment necessary

General Information

Common Usage

Common Usage

Anaerobic infections above the diaphragm, especially dental infection.

Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.

Skin & soft tissue infections involving susceptible MRSA.

Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.

For decreasing toxin production in toxic shock syndrome.

Drug Monitoring

Drug Monitoring

None specific. Monitor for diarrhea.

Major Interactions

Major Interactions

Muscle relaxants, e.g., atracurium, baclofen, diazepam.

St. Johns Wort

Pharmacology

Pharmacology

Antimicrobial class: Lincosamide

Pregnancy category: B

Average serum half life: 3 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic