Spectrum: Local Antimicrobial Stewardship, for Lake of the Woods District Hospital

Norfloxacin (Noroxin)

C. diff Risk

High

Oral Bioavailability

Moderate

Approximate Cost

~$0.25 / day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

400mg PO BID

Renal

General Information

Common Usage

Common Usage

Prophylaxis of spontaneous bacterial peritonitis.

Uncomplicated UTI.

Drug Monitoring

Drug Monitoring

Monitor QTc in patients with increased risk.

Adverse Effects

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

Major Interactions

Major Interactions

  • Other QTc prolonging agents.

  • Divalent cations - Decreased absoprtion.

  • Methadone - Increased seizures.

  • Thyroid replacement - Decreases T.

  • Warfarin - Increased INR.

Pharmacology

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Urine penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic