High
Excellent
PO ~$0.20/day
IV ~$6.00/day
Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites.
QTc prolongation
Dysglycemia
Tendinopathy and rupture
GI upset
Rash
Retinal detachment
CNS toxicity including confusion, psychosis
Weakness exacerbation in myasthenia gravis
CYP1A2 inhibitor - Multiple interactions possible.
QTc prolongation - Increased risk with other agents that prolong QTc.
Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption.
Cyclosporine - Increased levels of cyclosporine.
Warfarin - Increased INR.
Methadone - Lowered seizure threshold.
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 4 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Moderate
Biliary penetration: Therapeutic
