Spectrum: Local Antimicrobial Stewardship, for Lake of the Woods District Hospital

Meropenem (Merrem)

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

~$15.00/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Renal

General Information

Common Usage

Common Usage

Therapy of serious, often nosocomial infections involving resistant gram negative organisms.

Adverse Effects

Adverse Effects

  •  Immediate and delayed-type allergy

  •  GI disturbance

  •  Cytopenias, positive Coombs

  •  Liver enzyme abnormalities

Major Interactions

Major Interactions

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold.

Pharmacology

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic