Spectrum: Local Antimicrobial Stewardship, for Lake of the Woods District Hospital

Vancomycin IV (Vancocin)

C. diff Risk

None

Oral Bioavailability

None

Approximate Cost

~ $12.00/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Renal

Nomogram

General Information

Common Usage

Common Usage

Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections.

Order Set

Order Set

Order set is available here

Drug Monitoring

Drug Monitoring

Collect trough 0-1h before 3rd dose if abnormal/fluctuating renal function.

Target trough 15-20mcg/mL for most serious infections, 20-25mcg/mL for meningitis.

If trough low, increase dose OR decrease dosing interval (generally suggested to not exceed 2g/dose, but may be indicated in certain circumstances).

If trough >20, increase dosing interval or decrease dose.

Adverse Effects

Adverse Effects

  •  Nephrotoxicity

  •  Cytopenias

  •  Rash including Stevens-Johnson Syndrome

  •  Red man syndrome (histamine release- slow down infusion)

Major Interactions

Major Interactions

Aminoglycosides may potentiate nephrotoxicity.

May enhance neuromuscular blockade of NM blocking agents.

Careful with concomitant nephrotoxins.

Pharmacology

Pharmacology

Antimicrobial class: Glycopeptide

Pregnancy category: C

Average serum half life: 8 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Moderate