Spectrum: Local Antimicrobial Stewardship, for Lake of the Woods District Hospital

Aztreonam (Azactam)

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

Severe Infection2g IV q6-8h

Moderately Severe Infection1g IV/IM or 2g IV q8-12h

UTI500-1000mg IM/IV q8-12h

Renal

Not On Formulary

This medication is currently not on hospital formulary - please contact pharmacy if it is needed.

General Information

Common Usage

Common Usage

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent.

Nebulized form used in cystic fibrosis patients.

Empiric therapy for febrile neutropenia.

Drug Monitoring

Drug Monitoring

Monitor liver enzymes

Adverse Effects

Adverse Effects

  •  Elevated liver enzymes

  •  Cytopenias

  •  Eosinophilia

  •  Phlebitis at injection site

  •  Rash/allergy

  •  CNS toxicity

Major Interactions

Major Interactions

No significant interactions.

Pharmacology

Pharmacology

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate