Cefotaxime (Claforan)

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

~$35.00/day

Dosing

1-2g IV q4-12h

General Information

Common Usage

Empiric therapy for:

  •  Bacterial meningitis

  •  Pneumonia (in combination with a macrolide)

  •  Intra-abdominal infection including SBP

  •  Musculoskeletal i.e. septic arthritis

  •  Urinary tract infection

Adverse Effects

  •  Rash

  •  Localized phlebitis at injection site

  •  Allergy

  •  Positive Coombs test

  •  Neutropenia

  •  Abnormalities in liver enzymes

  •  Diarrhea

  •  CDI

Additional Information

Prefer ceftriaxone for CNS infection in renal failure.

Pharmacology

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate