Spectrum: Local Antimicrobial Stewardship, for CHEO-OCTC

Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

$3-4/day (Oral)

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

Neonatal

> 2 kg

  • 0 - 7 days: 150 mg/kg/day IV/PO divided Q8H

  • > 7 days: 200 mg/kg/day IV/PO divided Q6H

< 2 kg

  • 0 - 7 days: 100 mg/kg/day IV/PO divided Q12H

  • &gt; 7 days: 150 mg/kg/day IV/PO divided Q8H

General Information

First Line Indications

First Line Indications
  • First line therapy for all infections due to confirmed methicillin-sensitive S. aureus (MSSA)

Oral Liquids

Oral Liquids

Concentration: 25 mg/mL

Taste: Unpleasant taste

Not all strengths of oral liquids are listed nor be available on the CHEO Formulary

Tablet/Capsule Strengths

Tablet/Capsule Strengths

  • 250 mg

  • 500 mg

Tablets or capsules are preferred especially over an unpleasant tasting oral liquid.

Not all strengths of oral tablets/capsules are listed and they are not all available on the CHEO Formulary.