Spectrum: Local Antimicrobial Stewardship, for CHEO-OCTC

Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

NA

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Pediatric

IV Dosing

Daily Dose: 240 mg/kg/day of piperacillin component

Maximum Daily Dose: 16 g/day of piperacillin component

Dosing Frequency: IV divided q6h

Neonatal

< 2 kg

  • 0 – 7 days: 150 mg/kg/day divided Q12h

  • &gt; 7 days: 225 mg/kg/day divided Q8h

> 2 kg

  • 0 – 7 days: 225 mg/kg/day divided Q8h

  • &gt;7 days: 300 mg/kg/day divided Q6h

General Information

First Line Indications

First Line Indications

  • Suspected or confirmed infections due to P. aeruginosa

  • Empiric therapy for febrile neutropenia