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Pathogens
Antimicrobials
Enterococcal IE is generally treated for SIX weeks, and maybe longer for prosthetic valves
Gentamicin is generally continued for the duration of therapy but needs to be weighed against toxicities
The course starts from the first negative blood culture, and may require alteration if complications occur or the patient requires surgery/valve replacement
Vancomycin 25-30mg/kg IV load (max 2g) followed by 15mg/kg IV q12h maintenance for a target trough of 15-20µg/mL
AND
Gentamicin 1mg/kg IV q8h (trough <1µg/mL)
This regimen has significant risk of nephrotoxicity; close monitoring required
Day 3 Bundle
